2024

  • Non-Invasive Diagnosis of Heart Failure in Dogs, Identifying Unique Metabolic Signatures in Exhaled Breath – Dr. Chris Stauthammer, University of Minnesota, College of Veterinary Medicine ($54,000). CT Grant # 109. Duration: 12 months.
  • Effect of Oral Pimobendane on Echocardiographic Regurgitation Fraction and NT-proBNP in Dogs with Myxomatous Mitral Valve Disease – Marisa Ciccozzi, DVM, University of Minnesota, College of Veterinary Medicine ($32,475). CT Grant #110. Duration: 18-24 months.

2021

  • Developing A Novel Cardio-Protective Gene Therapy to Stop the Progression of Heart Failure in Dogs. – Rejuvenate Bio ($100,000 OPEN).
    • 2020-21 – Pilot Efficacy Study in Cavalier King Charles Spaniels
    • 2022-Follow-up on dogs in Pilot Study-2+ years
    • 2023-24-Preparation for and Distribution of the Treatment to Veterinarians Nationally

2019

  • Predicting Disease Stage and Diuretic Responsiveness in Dogs with Acquired Heart Disease  – North Carolina State University – Funded  by in cooperation with the AKC Canine Health Foundation and other Parent Clubs ($5,000-CLOSED) CHF Grant #2436.  Report
  • Three Dimensional Echocardiographic Determinants of the age of onset of Myxomatous Mitral Valve Disease in CKCS – Virginia-Maryland Regional College of Veterinary Medicine Funded by in cooperation with the AKC Canine Health Foundation, ACKCSC and Other Parent Clubs ($5,000.00-OPEN) CHF Grant #2649.  5/1/19 – 4/30/22.**

2018

  • Predicting Disease Stage and Diuretic Responsiveness in Dogs with Acquired Heart Disease – North Carolina State University – Funded  by in cooperation with the AKC Canine Health Foundation and Other Parent Clubs ($5,000-CLOSED) CHF Grant #2436.    5/1/18-10/31/19.

2017

  • Developing A Novel Cardio-Protective Gene Therapy to Stop the Progression of Heart Failure in Dogs. Rejuvenate Bio – Funded and in Partnership with American Cavalier King Charles Spaniel Club

($100,000.00-Open) CT Grant #107.5/1/2017-3/20/21*

2017-2019 – Safety Study in Beagles and Development of Treatment Dosage

2020-2021 – Pilot Efficacy Study in Cavalier King Charles Spaniels

2014

  • Early and Accurate Prediction of Mitral Valve Disease Development – Cornell University – Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs ($2,500-OPEN) CHF Grant #01994

2013

  • Enhancing Treatment of Mitral Valve Disease Through Identification of the Biological Markers of the Disease- Texas A & M – Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs ($2,500) CHF Grant #0186

2012

  • Development and Testing of a Novel Canine Annuloplasty Ring for Mitral Valve Repair – Michigan State University – Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs ($13,980) CHF Grant #107.

2009

  • Seratonin Type2A Receptor Antagonist Therapy for Preventing the Progression of Myxomatous Mitral Valve Disease – University of Pennsylvania School of Veterinary Medicine – Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs ($5,000) CHF Grant #908Note: This proposal represents a novel translational study that targets a potential underlying pathogenesis of canine mitral valve disease.
  •  Effect of Treatment with Low Doses of Hydrocortisone on Blood Pressure and Mortality in Dogs with Septic Shock – University of California, Davis School of Veterinary Medicine – Funded in cooperation with the AKC Canine Health Foundation And other Parent Clubs ($500) CHF Grant #856A
  • Tissue Regeneration using Canine Mesenchymal Stem Cells: Effects of Donor Characteristics and ex vivo Expansion on Cell Pluripotency – University of Pennsylvania School of Veterinary Medicine – Funded in cooperation With the AKC Canine Health Foundation and other Parent Clubs ($2,500)  CHF Grant #970Note: This research will bring promising stem cell therapies closer to reality in veterinary medicine including new therapies for heart failure.

2008

  • Molecular Characterization of Valvular Interstatial Cells in Canine Chronic Valvular Disease – Washington State University – Funded in Cooperation With the AKC Canine Health Foundation and other Parent Clubs.($2,500) CHF Grant #1026A

2007

  • Alteration in Protein Expression in Canine Myxomatous Mitral Valve Disease – University of Edinburgh ($6,480) CHF Grant #806A
  • Evaluation of Novel Diagnostic and therapeutic Modalities  for Treatment of Canine Pulmonary Hypertension – University of Missouri – Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs. ($1,000). CHF Grant #858

2006

  • Alteration in Protein Expression in Canine Myxomatous Mitral Valve Disease– University of Edinburgh, Scotland – Donation to this research by the ACKCS Charitable Trust ($6,480)
  • Mitral Valve Disease in Cavalier King Charles Spaniels – University of Pennsylvania – Funded by the ACKCS Charitable Trust ($63,446). Note:  Research began Sept. 1, 2006 with funds from an anonymous donor of $80,000